2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P99965
    Crovalimab 1917321-26-6 98.61%
    Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research.
    Crovalimab
  • HY-21088
    3-Amino-2-piperidinone 1892-22-4
    3-amino-2-piperidinone is a cyclic ornithine analogue. 3-amino-2-piperidinone can be used to synthesize N-(2-oxopiperidin-3-yl)dodecanamide. N-(2-oxopiperidin-3-yl)dodecanamide inhibits Fas-induced Apoptosis.
    3-Amino-2-piperidinone
  • HY-21268
    Methyl linolenate 301-00-8 99.46%
    Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids.
    Methyl linolenate
  • HY-B1114
    Gliquidone 33342-05-1 99.93%
    Gliquidone (AR-DF 26) is an anti-diabetic agent in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
    Gliquidone
  • HY-B1651
    Iron(II) fumarate 141-01-5
    Iron (II) fumarate is an orally effective active dietary supplement. Iron (II) fumarate can alleviate metabolic damage and damage to silkworms caused by cypermethrin (HY-123178). Iron (II) fumarate can be used for research on iron deficiency anemia.
    Iron(II) fumarate
  • HY-D0217
    Sulfobromophthalein disodium salt 71-67-0 ≥98.0%
    Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of agents and metabolites.
    Sulfobromophthalein disodium salt
  • HY-D1163
    Chromium(III) acetate 1066-30-4 99.9%
    Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD50 of 2365 mg/kg in rats.
    Chromium(III) acetate
  • HY-N0661
    Alliin 556-27-4 99.82%
    Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities.
    Alliin
  • HY-N1462
    Atractyloside potassium salt 102130-43-8 99.93%
    Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. Atractyloside potassium salt activates autophagy, inhibits ANT2, mTOR and promotes the activation of p-AMPK. Atractyloside potassium salt has anti-cancer effects on non-small cell lung cancer and can inhibit liver steatosis. Atractylodesin potassium salt has nephrotoxicity.
    Atractyloside potassium salt
  • HY-N7091
    Atrazine 1912-24-9 99.26%
    Atrazine, a triazine herbicide, is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term.
    Atrazine
  • HY-N8268
    Nordeoxycholic acid 53608-86-9
    Nordeoxycholic acid is a 23-carbon bile acid. Nordeoxycholic acid is a norcholic acid metabolite and a steroid human metabolite.
    Nordeoxycholic acid
  • HY-P2756
    Alcohol oxidase 9073-63-6
    Alcohol oxidase is a functional enzyme of methanol utilization pathway and can be isolated from yeast peroxisome.
    Alcohol oxidase
  • HY-P2799
    Creatine phosphokinase, Rabbit muscle 9001-15-4
    Creatine phosphokinase, Rabbit muscle (CPK) catalyzes the reversible reaction of creatine and ATP to form phosphocreatine and ADP. Creatine phosphokinase is a key enzyme for maintaining a constant ATP/ADP ratio during rapid energy turnover.
    Creatine phosphokinase, Rabbit muscle
  • HY-P2809
    Malic dehydrogenase, microorganism 9001-64-3
    Malate dehydrogenase (EC 1.1.1.37) (MDH) catalyzes the mutual conversion of oxaloacetate and malate, and is associated with the oxidation/reduction of dinucleotide coenzymes.
    Malic dehydrogenase, microorganism
  • HY-Y1031
    3-Ethoxy-3-oxopropanoic acid 1071-46-1 ≥98.0%
    3-Ethoxy-3-oxopropanoic acid is an endogenous metabolite. 3-Ethoxy-3-oxopropanoic acid promotes plant growth.
    3-Ethoxy-3-oxopropanoic acid
  • HY-109555
    Insulin glulisine 207748-29-6
    Insulin glulisine (HMR 1964) is a rapid-acting insulin analogue, it mimics the pharmacokinetic and pharmacodynamic profiles of physiological human insulin. Insulin glulisine can be used for the research of diabetes.
    Insulin glulisine
  • HY-109556
    Insulin Detemir 169148-63-4
    Insulin Detemir is an artificial insulin, shows effect on controlling blood sugar levels. Insulin Detemir stimulates GLP-1 secretion as a consequence of enhanced Gcg expression by a mechanism involving activation of Akt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways. Insulin Detemir can be used for type 2 diabetes research.
    Insulin Detemir
  • HY-111443
    TR antagonist 1 500794-88-7 99.57%
    TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
    TR antagonist 1
  • HY-113058
    3-Hydroxyoctanoic acid 14292-27-4 ≥98.0%
    3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.
    3-Hydroxyoctanoic acid
  • HY-113338
    8-Hydroxyguanine 5614-64-2 ≥98.0%
    8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage.
    8-Hydroxyguanine
Cat. No. Product Name / Synonyms Application Reactivity